It showed haemo- concentration due to fluid depletion in acute intestinal obstruction discount aurogra uk erectile dysfunction drugs not working. Serum electrolyte concentrations in acute intestinal obstruction were within normal control range order aurogra with american express erectile dysfunction juice drink. And also those values were within normal rane irrespective of the period of suffering from the course of disease before treatment. Accordingly, extensive research into diarrhoeal diseases has been carried out by scientists from the Department of Medical Research as well as by interested scientists from the Department of Health and the Department of Medical Education working in the hospitals, teaching institutions and various health services departments. In time series experiments, C-L- 14 glycine and C-lysine uptake were found to follow saturation kinetics (being saturated at 5min. Concentration series experiments were carried out to determine the Vmix and K oft these transport systems, which were not significantly different. On the other hand, transport 14 of C-Proline by amino acid transport system (iii) was not operation during cholera. This study demonstrates continued absorption of amino acids by three amino acid transport systems, providing scientific basis for use of amino acids in improved oral rehydration solutions in the treatment of acute diarrhoea, and emphasizes the importance of maintaining feeding during acute diarrhoea in order to prevent development of malnutrition. In time series experiments, 14C-L-glycine uptake was found to follow saturation kinetics (being saturated at 5min), to be blocked by uncouplers of oxidative phosphorylation (sodium fluoride and 2:4-dinitrophenol), and that 14C-L-glycine uptake by both amino acid transport system 1) and amino acid transport system 4) were active during the active purging stage of cholera. Concentration series experiments were carried out to determine the Vmax and Kt of these transport systems, which were not significantly different. This study demonstrates continued absorption of amino acids (glycine) by two amino acid transport systems, provides scientific basis for use of glycine in "improved" oral rehydration solutions in the treatment of acute diarrhea, and emphasizes the importance of maintaining feeding during acute diarrhea in order to prevent development of malnutrition. There were no differences between rice absorbers (peak hydrogen<10ppm above baseline) and rice malabsorbers in the allometric indices (the Ehrenberg index and the Dugdale index) allometric indices (the Ehrenberg index and the Dugdale index) of weight- for- length. By limulus amoebocyte lysate gelation test using chloroform extraction, endotoxin (lipopolysacchaide) was detected in half of patients with cholera and none of patients with noncholera diarrhoea. Of 185 patients with cholers, those gives tettacycline or tetracycline and berberine had considerably reduced volume and frequency of diarrhoeal stools, duration of diarrhoea, and required less intravenous and oral rehydration fluid. Analysis by factorial design equations, however, showed a reduction in diarrhoeal stools by one litre and reduction in cyclic adenosine monophosphate concentrations in stools by 77% in the groups given berberine. Considerably fewer patients given tetracycline or tetracycline and berberine excreted vibrios in stools after 24 hours than those given berberine alone. Neither tetracycline nor berberine had any benefit over placebo in 215 patients with non-cholera diarrhoea. Children who continued to be breast fed during treatment with oral rehydration solutions passed significantly fewer diarrhoeal stools. They also passed, on average, a smaller volume of diarrhoeal stools and recovered from diarrhea sooner after the start of treatment. Breast feeding exercise a beneficial effect on the course and outcome of acute diarrhea by reducing the number and volume of diarrhoeal stools. Of 185 patients with cholera, those given tetracycline or tetracycline and berberine had considerably reduced volume and frequency of diarrhoeal stools, duration of diarrhoea, and volumes of required intravenous and oral rehydration fluid. Analysis by factorial design equations, however, showed a reduction in diarrhoeal stools by one litre and a reduction in cyclic adenosine monophosphate concentrations in stools by 77% in the groups given berberine. This pattern was similar to the prevalence of acute children diarrhoea in these village children. The rate of recovery from dehydration (as demonstrated by reduction in haematocrits) were almost, identical. There was a definite seasonality for acute diarrhoea, the incidence rates during the monsoon months being significantly higher than those during the winter months. Bacterial agents, especially enterotoxigenic Escherichia coli, were the most common pathogens foracute diarrhoea during monsoon, and rotavirus was the most common pathogen detected during winter. Presumably, because of the cytopathic effect of rotavirus, children who developed diarrhoea during winter had smaller gain in body weights per month than those who developed diarrhoea during monsoon (being most commonly associated with enterotoxigenic Escherichia coli ). It is found that below age 30, the disease is rare and the peak incidence being age 51 to 60. Of 50 cases, gastric resections are performed on 19 patients (38 percent), gastrojejunostomy (palliative by-pass procedure) on 24 patients (48 percent) and on 7 patients (14 percent) neither resection or palliative by-pass could be done, laprotomy and biopsy only could be done. The common clinical presentations are vague abdominal pain (mainly in epigastrium) not relieved by antacids, dyspesia and presence of clinically palpable epigastric lump. It is found that the presence of palpable epigastric lump lessens the resectability rate. In this study, of 19 cases of gastric resection, 12 patients (64 percent) have no clinically palpable epigastric lumps. It is found in the study that those who have their time-lapse over four months, the gastric resection rates are much reduced. In this study 80 percent of the growths are found situated in the pyloric antrum and the rest in the body and fundus. In this study, of 19 cases resected, 11 acses (56 percent) have local spread and 8 cases (42 percent) have intra-abdominal spread. Surgeons of consultant level have the greater skill than their first assistants to perform gastric resections. When keeping controls with the same type of spread of the disease and the same sizes of growth, the resection rates are still higher in the consultant level group than those in their junior colleagues. These neonates also lost more sodium in their stools than their non diarrhoeic counterparts. On the other hand, the diarrhoeic newborns lost less potassium in stools in the first few days. In the process of making these sweets, there are many ways by which they can get contaminated. The percentage isolation of enteric bacteriae was the highest in the sweet-damp types and during the hot-wet season. The enteric bacteriaea were isolated more in tamarinds and the plums and the least in marian group. The Myanmar fruit sweets may be one of the potentially important vehicle to transmit diarrhoeal pathogens during the hot-wet season in Myanmar. Improvements in the personal and environmental hygiene are needed to prevent contamination during their production. From the morning meals and stored drinking water of 208 randomly selected children, 775 food and 113 water samples were collected and were cultured using standard methods. Enterotoxigenic Escherichia coli, salmonella spp, shigella spp, and non-O1 Vibrio cholera were isolated from fly pools in animal pens (88. The gastroenteritis caused by these bacteria is caused by these bacteria is accompanied by pain in abdomen, nausea and vomiting, fever and a mild degree of dehydration. This is the first report indicating the frequency and importance of Aeromonas and Plesiomonas species in causing gastroenteritis in Myanmar. It is anticipated to facilitate the epidemiological study in order to provide an effective control of the disease.

Sympatho- mimetic agents were seen to evoke inhibitory responses where parasym-pathomimetic agents were found to evoke excitatory responses buy cheapest aurogra erectile dysfunction doctors boise idaho. Neurohistological and histochemical studies were done on the specimens from fifteen human adults cheap aurogra amex impotence erectile dysfunction, three human fetuses, eight albino-rats, and four specimens from human operative biopsy tissue. All parts of the stomach were supplied by the gastric branches of the coeliac plexus formed by both th th vagi and greater splanchnic nerves mainly from 6 to 9 thoracic ganglia. Neurohisto- chemically nerve plexuses and ganglia were observed in the submucosa, muscular, and serosa layers of the stomach. Intraepithelial free nerve endings, free but organized nerve endings such as loop-like endings and encapsulated endings such as Meissner s corpuscle and small bulbous corpuscles were 190 Bibliography of Research Findings on Gastrointestinal Diseases in Myanmar seen. Histochemicaly, acetylcholinesterase - positive ganglia, varicose nerve fibres and formaldehyde fluorescent nerve plexus were observed. Pharmacological experiments with sympathomimetic agents, sympatholytic agents, parasympathomimetic agents, and parasym- patholytic agents were done in the stomachs of two albino-rats to prove the sympathetic and parasympathetic activities. The review also outlines the rational approach to promotion of growth of Myanmar children. Studies conducted in Myanmar have shown that rice malabsorption is common in children, and may occur in up to two thirds of the population. It is possible that Helicobacter pylori infection frequently acquired during childhhod in developing countries has an impact on small bowel function. The precise mechanism is unknown but it has been proposed that it relates to the impact of infection on acid secretion, resulting in hypochlorhydria which may open the gate to enteric infections, small bowel bacterial overgrowth, and associated carbohydrate malabsorption. Elucidation of these mechanisms would allow a rational approach to promotion of growth of Myanmar children. An increase in the number of siblings was also found to be a high risk factor for H. Density of living, drinking water source, and type of latrine were not significantly associated with H. The findings indicated that intrafamilial transmission could play an important role in the high prevalence of H. Before implementation of clinical use of such a serological test requires validations for local use. Again growing popularity of "test- and-treat" policy requires evaluation of usefulness of such serological test-performance among under and over forty-five years age groups. The objectives were: a) to compare the gastric acid secretion together with urine acid output between malnourished and well-nourished children, b) to determine the relationship between the gastric acid secretion and urine acid out put. The study was carried out during June to December 2000 at the Yangon Children Hospital. Gastric acid secretion and urine acid output level before and after coffee stimulation in 40 malnourished and 20 well-nourished children. It was found that there was significantly decreased volume of stimulated gastric acid secretion within first hour (17. However, there was no significant quantitative relationship between gastric acid secretion and urine acid output in both malnourished and well-nourished children. Malnourished children were unable to respond appropriate to a stimulus for gastric acid production, poor response was markedly observed in children with kwashiorkor and lesser extent in marasmic-kwashiorkor children. All these patients underwent semi-urgent haemorrhoidectomy (Standard Ligation and Excision). During hospital stay, early post-operative complication were elected and compared with other series. On each visit of the follow-up, late post- operative complications was explored and the results were also compared and discussed with the other series. Study was done regarding the incidence, clinical presentation, pathological staging and type of operation and postoperative complication. The youngest one was 23 years old man (medical student) the oldest one was 75 years old man. However, the peak age incidence as well as average age incidence was one decade earlier than the counterparts in the Western countries, but similar to that of Egyptians and South African Bantu. But the commonest symptoms of colorectal cancer are extremely varied and nonspecific. But the commonest symptoms after final result include bleeding per rectum (50%) and changing bowel habit (46%). Regarding distribution of colorectal cancinoma in this study, in most of the patients, tumour were siturated in the rectum (50%). Microscopic manifestation revealed that, most of the cases were adenocarcinoma (69. According to histological grading, most of the cases were placed in moderately differentiated (54. In clinical staging, most of the cases by the time of admission were more or less in advance stage and so there was staging of Dukes C2 (44. Duke B is only seen in 5 cases 193 Bibliography of Research Findings on Gastrointestinal Diseases in Myanmar (10. Because of most of the cases in this study was rectal tumour, abdomino-peritoneal resection 34. Immediate postoperative complication in this study shows mainly of local complication likes wound sepsis including both abdominal (10. The goal of surgery for colorectal carcinoma is to remove all cancerous tissue, while minimizing treatment related morbidity and mortality. There is no major and gross postoperative complication and mortality rate is also within standard limit. Many colorectal carcinoma only produce vague, nonspecific symptoms and asymptomic. Ideally this surgical emergency can be avoided by early recognition of changes in bowel habit is important and per rectal examination may help early diagnosis. Awareness and health education about colorectal carcinoma in public is also important. It has long been used in Myanmar traditional medicine for the treatment of amoebic dysentery for years. Infection was confirmed on fourth day through detection of trophozoites in mice stools. The antiamoebic activities of both extracts were compared with a group of infected mice receiving metronidazole, normal saline and with a group of non infected mice. On the fifth day, the mice were sacrificed and the caecum was examined macroscopically for lesions at caecal wall and contents. Therefore, it can be concluded that both extracts had dose dependent antiamoebic effect. There are many associated or precipitating factors for upper gastrointestinal bleeding. Moreover, risk stratification for patients with acute upper gastrointestinal bleeding can discriminate between patients at high or low risk of rebleeding or death.

Thus higher employment levels will be associated with greater potential economic loss buy discount aurogra 100 mg on-line impotence kit. In another words generic 100 mg aurogra with mastercard how to get erectile dysfunction pills, the actual economic loss may be less if there is high unemployment or under-employment. However, there will inevitably be large social losses with every premature death, which is not counted in the model, such as the premature death of parents that result in orphans. They also continue to require medical treatment including drug costs and health worker time. Again, those costs will vary a great deal according to the severity of the disease. The morbidity burden is estimated using a cost-of-illness approach, restricting the initial analysis to diabetes due to data limitations. The prevalence of diabetes projections comes from the Global Status Report on Noncommunicable Diseases 2014, which provided the 2014 prevalence rates of raised blood glucose. The 2015 and 2040 (International Diabetes Federation) diabetes prevalence rates allow projections, using a constant growth rate, for growth rates ranging from 0. The projection for all other years is then scaled back to 2015 by assuming that the three disease burdens grow at the same rate as the diabetes morbidity burden. An implicit assumption of this method is that those countries with higher diabetes morbidity costs will also have higher cardiovascular diseases, chronic respiratory disease, and cancer prevalence rates. The data is organized by the three major geographic areas in the Pacific: Melanesia, Polynesia, and Micronesia. The economic burden due to diabetes is highest among Polynesian countries, particularly in Tuvalu. Melanesian countries are currently experiencing a lower economic burden due to diabetes, but the burden is projected to rise quickly. The cost of diabetes is already quite high in most Micronesian countries and will continue to rise. This burden will be further compounded by the high stunting rates for children under five, particularly in Papua New Guinea. The steep slope of the burden curve, over the analysis time period, indicates the severity of the problem if no action is taken to reduce diabetes morbidity. Scenario 1 resulted in a significant burden reduction but the cost curve still increased for most countries included in the analyses. The modeling demonstrates that bending the cost curve may result in substantial economic, as well as obvious health benefits. Intervention methods to reduce incidence will vary for individual countries according to the incidence and prevalence trends, risk factors, cost of prevention and treatment, and availability of trained health workers and specialized equipment. Stakeholder analysis identifies numerous areas where multisector approaches are needed. Development partners also have an interest in supporting a multisector approach through their investments in infrastructure, other sectors, and trade policies. This was the first joint meeting of ministers responsible for economics and finance, and ministers for health in the Pacific. They also jointly agreed to the following five strategic action areas (Secretariat of the Pacific Community, 2014): i. Strengthen tobacco control by an incremental increase in excise duties to 70 percent of the retail price of cigarettes over the medium term; ii. Consider a tax increase for alcohol products as a way of reducing harmful alcohol consumption; iii. Improve the efficiency and impact of the existing health budget by reallocating scarce health resources to targeted primary and secondary prevention measures for cardiovascular disease and diabetes, including through the Package of Essential Noncommunicable Disease Interventions; and v. Strengthen the evidence base to enable better investment planning and programme effectiveness, thereby ensuring that interventions work as intended and provide value for money. It is quite common for good policy to be developed and laws enacted in developing countries, only to find that actual implementation is neglected or not given adequate resources and attention (Thomas & Grindle, 1990). Many factors contribute to weak implementation: inadequate financing and resourcing; weak or ambiguous lines of accountability; weak monitoring and evaluation; perceptions that leaders and managers are no longer interested in the issue; and opposition to change by vested interests. The economic costs are the ineffectual use and wasted time of leaders and managers who developed a policy that was not implemented properly. This imposes a particularly high cost in the Pacific where the time, energy, and political/ bureaucratic capital of skilled leaders and managers is a precious resource that should not be wasted. The political cost is the erosion of leaders credibility and authority when the population fails to see tangible follow up to a declared crisis. Individual countries are in the best position to determine implementation priorities, how to budget and resource implementation, and how to hold agencies and individuals responsible and accountable for results. Tobacco control There has been some progress around the recommendations for tobacco control. All 11 countries covered by the Pacific Possible report with the exception of Tuvalu have increased taxes on tobacco or are in the process of doing so. However, there are significant gaps in the implementation of tobacco control recommendations. Second, countries need to proactively measure and analyze the sales, additional revenue, and consumption trends of tobacco in light of excise duties and other interventions. It does not appear that any Pacific Island countries established a baseline of sales and revenue prior to the increase in excise duties. Unfortunately, the lack of evidence base does not allow policy makers to fine tune policies and meet government objectives or to defend themselves against the inevitable criticisms of the tobacco industry. As noted previously, parts of the Pacific have some of the highest levels of obesity in the world. Excessive alcohol consumption is associated with domestic violence, traffic accidents, and certain cancers. However, many factors affect dietary choices including the price and availability of healthier fruits and vegetables, advertising, and knowledge and awareness of the benefits of healthy eating. There are also ongoing efforts to introduce food safety regulations requiring nutrition labels on processed foods. Of the few countries that have raised the price of unhealthy foods and drinks, none have measured the change in consumption levels to see if the policy is working or cost effective. There is little information available about reducing salt consumption, including in processed foods. Nor is there good information to promote the growing and marketing of more nutritious foods, including fruits and vegetables. Improving the efficiency and impact of the health budget Improving the efficiency and impact of the existing health budget by making better use of existing financial, human, and other resources in the health sector is a major strategic priority for countries. The starting point for responding to the growing challenges in the health sector is to make sure that ministries of health are making the best use of existing financial and human resources. There is a good deal of capacity to strengthen the planning, priority setting, resource allocation, and financial management of existing budgets in the Pacific Island countries. Such efforts would help free up existing resources that can be allocated to higher impact and more sustainable investments. Reallocating scarce resources to well-targeted primary and secondary preventions is particularly relevant to achieve improved health outcomes in a way that is affordable, cost- effective, and financially sustainable.

The Committee s view is that we presently lack the infrastructure required to produce a dramatically improved disease taxonomy discount 100 mg aurogra free shipping erectile dysfunction treatment testosterone. Rather buy aurogra 100mg line impotence exercises for men, we propose a path forward to develop the infrastructure and research system needed to create the Knowledge Network of Disease that we believe would be an essential underpinning of a molecularly-based taxonomy. Just as public leadership and investment played essential roles in bringing the world-wide web into existence, we believe such investment will be critical if we are to achieve a grand synthesis of data-intensive biology and medicine. However, we also recognize that, just as the world-wide web needed to pay its own way before it could truly flourish, the Knowledge Network and its underlying Information Commons will need to do the same. The Committee believes that initiatives will be required in three areas to exploit the wealth of information now emerging on molecular mechanisms of disease by creating a dynamic and comprehensive, yet practical and widely-used, Knowledge Network: 1) Design of appropriate strategies to collect and integrate disease-relevant information. The Information Commons would be developed by linking molecular data to patient information on a massive scale. Creating a system for establishing this linkage for increasing numbers of individuals and making the resulting data widely available to researchers is the key step in moving toward a Knowledge Network and New Taxonomy. Such coupled data can be generated in several ways including the modest- scale, targeted molecular studies on patient materials that dominate current practice. However, the most direct and effective discovery paradigm involves observational studies which seek to relate molecular data to complete patient medical records available as by-products of routine healthcare. Effective follow-up of the most promising hypotheses generated through such studies will require laboratory-based biological investigations designed to seek explanations at the biochemical or physiological levels. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease 52 2) Implementation of pilot studies to establish a practical framework to discover relationships between molecular and other patient-specific data, patient diagnoses and clinical outcomes. The new discovery model will involve the mining of large sets of patient data acquired during the ordinary course of healthcare. Pilot studies designed to identify and overcome obstacles to successful implementation of this approach will be required before a set of best practices can emerge. Current policies on consent, confidentiality, data protection and ownership, health-cost reimbursement and intellectual-property will need to be modified to ensure the free flow of research data between all stakeholders without compromising patient interests. A new discovery model for disease research The current model for relating molecular data to diagnoses and clinical outcomes typically involves abstracting clinical data for a modest number of patients from a clinical to a research setting, then attempting to draw correlations between the abstracted clinical data and molecular data such as genetic polymorphisms, gene-expression levels, and metabolomic profiles. When discoveries are judged definitive and potentially useful, an effort is made to return this information to the clinical setting for example, as a genetic or genomic diagnostic test. This model creates a large gulf between the point of discovery and the point of care with many opportunities for mis- and even non-communication between key stakeholders. The current model also fails to exploit the wealth of molecular data that are likely to be generated routinely in the future as personalized genomics and perhaps other personalized omics become routine in clinical settings. Perhaps most seriously, the current discovery model offers no path toward economically sustainable integration of data-intensive biology with medicine. The Committee views it as both desirable and ultimately inevitable that this discovery model be fundamentally transformed. Instead of moving clinical data and patient samples to research groups to allow analysis, the molecular data of patients should instead be directly available to researchers and health-care providers. The Committee recognizes that this is a radical departure from current practice and one that faces significant challenges, nonetheless, because we believe this new discovery model would have dramatic benefits, we believe that aggressive steps should be taken to implement it. Indeed, there are concrete instances of research initiatives already underway that substantiate the Committee s belief that a special effort to implement its core recommendations can be achieved. Kaiser members were asked to participate in a study that would allow genetic and other molecular data to be compared with their full electronic health records. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease 53 study has faced major hurdles, and required more than 10 years to progress from its conceptualization to large-scale acquisition of genetic data. A pivotal challenge was to build trust between Kaiser s members, management, and oversight groups such as the relevant institutional review boards. While all parties recognized it was essential that the Kaiser members who were being asked to opt in to the research study be fully aware of its aims, the outreach infrastructure required to educate members had to be created nearly from scratch. A second major challenge was acquiring funding to cover the cost of generating extensive molecular data that lacked direct and immediate relevance to patient care a responsibility that Kaiser itself could not be expected to take on given the pressure to constrain health-care costs. Moreover, changing perceptions about what constitutes appropriate informed consent required costly and time-consuming reconsenting of the participants. Nonetheless, the ability of committed investigators working within strongly supportive institutions to overcome these obstacles has been impressive: nearly 200,000 Kaiser members have joined the study and large- scale data collection is now underway. In order to address and resolve these hurdles, the Committee envisions the design of several targeted pilot studies. These studies would probe key aspects of this new research paradigm and demonstrate to health-care providers the value of a molecularly informed taxonomy of disease. By demonstrating value for patients, the pilot studies will seek to lay the groundwork for a sustainable discovery model in which relevant clinically validated molecular data are routinely generated at the point of care because they meet the commonly accepted risk-benefit criteria that apply to all clinical test results. Pilot Studies should draw upon observational studies As emphasized above, the Committee believes that much of the initial work necessary to develop the Information Commons should take the form of observational studies. In this context, what we mean by observational studies is that, although molecular and other patient-specific data would be collected from individuals in the normal course of health care, no changes in the treatment of the individuals would be contingent on the data collected. This approach to discovery is already in use today, although most current initiatives draw in a very limited range of clinical data. For example, genome-wide association studies comparing individuals with and without a diagnosis of Crohn s disease securely identified a number of gene variants that implicate autophagy in the pathophysiology of Crohn s disease while similar comparisons for Age Related Macular Degeneration implicated complement factor H (McCarthy et al. In other instances, clinically relevant genotype-phenotype correlations have been discovered in the course of observational studies performed during randomized clinical trials. For example, a randomized clinical trial was performed to compare the efficacy of different formulations of interferon alpha in the treatment of chronic infection with hepatitis C. The enrollment of individuals in these studies had no bearing on their diagnoses, treatments, or in most cases, anything else in their lives. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease 54 was simply to ask the question Are there gene variants in the general population that are associated with who ends up with a particular diagnosis or experiences a particular treatment response? For example, there are likely to be a great many ways to classify patients based on molecular data, and only some will have clinical utility. In general, clinical utility will need to be evaluated using randomized clinical trials. Observational studies will also need to be followed by functional studies that seek to determine the mechanistic basis of observed molecular associations with clinical outcomes. We anticipate that laboratory based research of this sort will be essential to elucidate the underlying reasons for observed associations between molecular data and clinical outcomes and that these mechanistic insights will play an essential part in establishing the Knowledge Network and guiding its use. Be of a sufficient size, as well as scientific and organizational complexity, to reveal on the basis of actual experience the most significant barriers to the development of point- of-care discovery efforts. Address one or more unmet medical needs for which deeper biological understanding of a disorder would likely lead to near-term changes in treatment paradigms and health outcomes. Be led by an organization charged with delivering healthcare with strong partnerships with researchers. Seek to remove barriers to data sharing and provide an ethical and legal framework for protecting and respecting individual rights. Draw on laboratory research to assess the biological underpinnings of associations between molecular data and clinical outcomes.

P. Emet. Piedmont College.